Application Bulletin AP5R1
Quadro Comil
 

DRY GRANULATION APPLICATION
 

Background/Requirement

A large international pharmaceutical manufacturer approached Quadro with an application to reduce the size of a small percentage of oversized particles contained within a dry granulation. A 100 to 200 U.S. standard mesh lactose powder was mixed with active medicinal ingredient in a V-cone blender. The blending action produced approximately 4% (+) 20 mesh lumps while leaving the rest of the product properly sized. Due to problems encountered in sifting such a fine powder at a high rate, the customer wanted to size reduce the oversize particles directly from the blender without changing the particle size distribution of the rest of the product. The desired capacity was 1,500 pounds per hour (682 kg/hr).

Comil Performance

Due to the Comil’s gentle grinding action and quick discharge of already properly sized particles, a 100% (-) 20 U.S. standard mesh powder was produced without a significant change in the particle size distribution of the original infeed material. Test capacity was 3,900 lb/hr (1,750 kg/hr).

Summary

The Comil was supplied with such options as an adjustable height frame, explosion proof electrics and a special infeed chute. The Comil has become an integral step between the customer’s blending and tableting operations.