Application Bulletin AP16
Quadro Comil
 

COMIL PHARMACEUTICAL APPLICATIONS

 

Pharmaceutical companies worldwide are successfully using the Quadro Comil for wet granulations before drying, sizing after drying, granulating in the pre-compression stage, homogeneous mixing, conditioning, and dispersion of pigments in the manufacture of tablets. The versatile Comil can be used for:

WET GRANULATION SIZING

The Comil produces uniformly sized particles at very high capacities from a lumpy granulation. The granulation dries rapidly, uniformly and case hardening is eliminated. Case hardening causes sticking at the punches during tableting, unnecessary fines and extended drying time.

 

 

DOUBLE COMPRESSION

Direct compression blends are pre-compressed, granulated, then pressed into tablets. Ribbons from the roller compactor or slugs from pre-compression can be size reduced with a Comil to granules with optimum particle size distribution.

 

 

DRIED GRANULATION SIZING

The Comil sizes dry granulation to the optimum particle size distribution for efficient tableting.

 

 

 

TABLET/CAPSULE RECLAIM

“Off spec” tablets are reduced for reclaim purposes. “Off spec” capsules are broken into large pieces allowing for easy separation of powder from the gelatin pieces.

 

 

INGREDIENT CONDITIONING

Ideal for a broad range of delumping, mixing, finishing and milling. Lump-free homogeneous dry ingredient blending. Low heat build-up and precise screen size ensure complete dispersion, at desired particle size.